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Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide

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The increased endothelial cell permeability is generated by TGF1 via SMAD3-dependent signaling, which upregulates matrix metalloproteinase-9 and downregulates claudin-5